Moon of Alabama has a thoughtful argument as to the the diminishment of US influence due to the new conflict in the Levant:
West's Pro-Israel Position Accelerates Its Loss Of Power
In the article, they quote extensively from a Naked Capitalism article:
The gist is that no matter what we do, we can't put the humpty dumpty of world order back together again.
Now of course, here at the Neutralist, recognizing that in real terms that the games is up is always a reason to recognize we need to pursue a neutralist foreign policy.